The study aims to investigate the association between psychological stress level and development of cardiovascular disease (CVD) and death, involving populations from 21 high-, middle-, and low-income countries across 5 continents. Researchers found out that higher psychosocial stress, measured as a composite score of self-perceived stress, life events, and financial stress, was significantly associated with mortality as well as with CVD, CHD, and stroke events. The results emphasize the need for the development and evaluation of prevention strategies to address whether modifying stress would reduce CVD.